Enantioselective Synthesis of Succinimides by Michael Addition of 1,3-Dicarbonyl Compounds to Maleimides Catalyzed by a Chiral Bis(2-aminobenzimidazole) Organocatalyst
نویسندگان
چکیده
A wide variety of chiral succinimides have been prepared in high yields and enantioselectivities by an asymmetric conjugate addition of 1,3-dicarbonyl compounds to maleimides under very mild reaction conditions using the bifunctional benzimidazole-derived organocatalyst 5f. Computational and NMR studies support the hydrogen-bonding activation role of the catalyst and the origin of the stereoselectivity of the process.
منابع مشابه
Organocatalytic Asymmetric α-Chlorination of 1, 3-Dicarbonyl Compounds Catalyzed by 2-Aminobenzimidazole Derivatives
Bifunctional chiral 2-aminobenzimidazole derivatives 1 and 2 catalyze the enantioselective stereodivergent α-chlorination of β-ketoesters and 1,3-diketone derivatives with up to 50% ee using N-chlorosuccinimide (NCS) or 2,3,4,4,5,6-hexachloro-2,5-cyclohexadien-1-one as electrophilic chlorine sources.
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